SOLVADYS®
Oral small molecules
We assess multiple aspects of endothelial dysfunction to identify candidates that improve impaired function.
OUR APPROACH
Drug development targeting endothelial dysfunction
Curacle focuses on endothelial dysfunction involved in the onset and progression of intractable, chronic and age-related diseases, developing medicines to restore normal vascular function.
Microvascular function
Microvessels deliver oxygen and nutrients to tissues and help remove waste products. The endothelial cells lining these vessels regulate exchange between blood and tissue and play a key role in maintaining blood flow and tissue function.
Barrier integrity
Regulates exchange through cell–cell junctions and limits excessive leakage
Oxygen & nutrient delivery
Supports blood flow and exchange according to tissue needs
Inflammatory & thrombotic regulation
Restrains leukocyte adhesion and excessive inflammatory and thrombotic activation
Endothelial Dysfunction
Endothelial dysfunction is a loss of normal endothelial regulation that disrupts the balance of barrier function, blood flow, inflammation and coagulation. Aging, high blood glucose, chronic inflammation and oxidative stress can contribute to this impairment.
Weakened cell–cell junctions can allow excessive fluid and protein leakage into surrounding tissue, causing edema. Impaired control of vascular contraction and relaxation can reduce tissue perfusion and oxygen delivery, while increased leukocyte adhesion and platelet activation can promote inflammation and thrombus formation.
Persistent dysfunction can contribute to tissue injury and impaired organ function. Endothelial dysfunction occurs across organs, including the retina, kidney and brain, and is involved in the onset and progression of diverse intractable, chronic and age-related diseases.
Normal microvascular functionEndothelial dysfunction
Swipe horizontally to view the full diagram.
01Junction breakdown
02Leakage & edema
03Impaired perfusion & hypoxia
04Inflammatory & thrombotic activation
Endothelial dysfunction:
a vicious cycle
a vicious cycle
A cycle of vascular dysfunction and tissue injury
Leakage and edema following barrier damage, impaired blood flow, and inflammatory and thrombotic activation interact to worsen vascular dysfunction and tissue injury.
Two complementary strategies to restore vascular function
Curacle develops medicines that target endothelial dysfunction to restore normal vascular function.
EAGLES® · Co-developed with MabTics
Antibody biologics
We develop antibodies that activate protective vascular signals or inhibit disease-driving signals, combining mechanisms through bispecific and multispecific formats.