MT-202 – Ischemic Stroke
An investigational bispecific antibody for inhibition of thrombus formation and vascular protection
PDI Inhibition and Tie2 Activation by MT-202
Modality
PDI/Tie2-targeting bispecific antibody
Mechanism of Action
PDI inhibition for antithrombotic activity combined with Tie2 activation for vascular stabilization, addressing thrombus formation and endothelial injury
Target Indications
Ischemic stroke
Development Status
Preclinical studies in progress
Key Differentiators
Antithrombotic and vascular-protective mechanisms combined in a single bispecific antibodyDevelopment targeting endothelial injury and vascular dysfunction during ischemia and reperfusionAn approach aiming to combine thrombosis control and vascular stabilization while minimizing bleeding risk
Market Opportunity
In ischemic stroke, restoring blood flow must be accompanied by efforts to limit bleeding risk and vascular injury associated with reperfusion. MT-202 adds a vascular-protective mechanism to antithrombotic activity, with the goal of addressing limitations of existing treatment approaches.
Development & Partnership
Co-developed with MabTics