ENDOTHELIAL DYSFUNCTION

Endothelial dysfunction (ED) is an early pathogenic feature of cardiovascular morbidities, consisting of impaired vasodilation, angiogenesis and barrier function.
It has been related to metabolic diseases such as diabetes mellitus, obesity or metabolic syndrome all of them also associated with cardiovascular diseases.
The key role of oxidative stress and inflammation in the pathogenesis of ED is well established. 

Pathological status

Healthy Endothelium

Endothelial Dysfunction

Adapted from Frontiers in Medicine (2022)

Disease

Since endothelial dysfunction is related to blood vessels, and blood vessels run through the body, Endothelial Dysfunction is systemic and is closely associated with many diseases, such as retinopathy, and cardiovascular and cerebrovascular disease.

Diseases	Curacle’s Publications
Diabetic retinopathy	Euro J Phar (2011)
Myocardial infarction (ischemia-reperfusion injury)	Exp Mol Med (2022)
Stroke (ischemia-reperfusion injury)	J Mol Med (2020)
	J Neuroinflammation (2017)
Ulcerative colitis	Front. Pharmacol. (2020)
Tumor	Oncotarget (2014)
anti-angiogenic agent combination	BBRC (2014)
Anti-PD1 combination	Front. Immunol. (2021)

Source: Arteriosclerosis, Thrombosis, and Vascular Biology (2019)

Current treatment

The current treatment strategy focuses on a single target or dual targets at most. That single target could be a cytokine, as in the case of Anti-TNF or different enzymes, etc.
Highly effective protector of endothelial dysfunction working independently on multiple mediators.